منابع مشابه
γH2AX spreading linked to homology search
*Correspondence to: Stefan Jentsch; Email: [email protected] Submitted: 06/03/2013; Accepted: 06/05/2013 http://dx.doi.org/10.4161/cc.25836 Comment on: Renkawitz J, et al. Mol Cell 2013; 50:261-72; PMID:23523370; http://dx.doi.org/10.1016/j.molcel.2013.02.020 DNA double-strand breaks (DSBs) are one of the most toxic types of DNA damage, as their inaccurate repair results in mutations and c...
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متن کاملModern Homology Search
Dynamic programming [1] has full sensitivity, but too slow for large scale homology search. FASTA / BLAST type of heuristics [2] trade sensitivity for speed. Can we have both sensitivity and speed? We present the mathematical theory of optimized spaced seeds which allows modern homology search to achieve high sensitivity and high speed simultaneously. The spaced seed methodology is implemented ...
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MOTIVATION Life science researchers often require an exhaustive list of protein coding genes similar to a given query gene. To find such genes, homology search tools, such as BLAST or PatternHunter, return a set of high-scoring pairs (HSPs). These HSPs then need to be correlated with existing sequence annotations, or assembled manually into putative gene structures. This process is error-prone ...
متن کاملHomology Search Methods
Homology search methods have advanced substantially in recent years. Beginning with the elegant Needleman-Wunsch and Smith-Waterman dynamic programming techiques of the 1970s, algorithms have been developed that were appropriate for the data sets and computer systems of their times. As data sets grew, faster but less sensitive heuristic algorithms, such as FASTA and BLAST, became a dominant for...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2013
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.25836